Design and Analysis of Vaccine StudiesSpringer Science & Business Media, 2009 M10 27 - 390 páginas As well as being a reference for the design, analysis, and interpretation of vaccine studies, the text covers all design and analysis stages, from vaccine development to post-licensure surveillance, presenting likelihood, frequentists, and Bayesian approaches. |
Contenido
| 1 | |
2 Overview of Vaccine Effects and Study Designs | 19 |
3 Immunology and Early Phase Trials | 47 |
4 Binomial and Stochastic Transmission Models | 63 |
5 R0 and Deterministic Models | 85 |
6 Evaluating Protective Effects of Vaccination | 103 |
7 Modes of Action and TimeVarying VES | 131 |
8 Further Evaluation of Protective Effects | 153 |
11 Analysis of Households in Communities | 235 |
12 Analysis of Independent Households | 257 |
13 Assessing Indirect Total and Overall Effects | 271 |
14 Randomization and Baseline Transmission | 313 |
15 Surrogates of Protection | 337 |
Solutions | 359 |
References | 361 |
| 381 | |
Otras ediciones - Ver todas
Design and Analysis of Vaccine Studies M. Elizabeth Halloran,Ira M. Longini, Jr.,Claudio J. Struchiner Sin vista previa disponible - 2012 |
Design and Analysis of Vaccine Studies M. Elizabeth Halloran,Ira M. Longini, Jr.,Claudio J. Struchiner Sin vista previa disponible - 2009 |
Términos y frases comunes
analysis antibody approach ascertained assignment assumed assumption attack rate average Bangladesh become infected bias called carriage causal cells Chapter clinical compared computed consider covariates defined definition denote dependent developed disease distribution effect effects of vaccination epidemic equation estimate et al evaluate example expected exposed exposure to infection Figure given Halloran hazard household immune incidence included increase indirect individuals infectious agent influenza interest intervals intervention measure methods observed occur outcome parameters participants period person pertussis vaccine placebo pneumococcal population possible post-infection potential present primary probability proportion protection randomized ratio received reduce relative response risk sample secondary selection severe statistical status surrogate susceptible Table tion transmission transmission probability treatment trial unit unvaccinated group vaccine effects vaccine efficacy vaccine studies values