Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical ImplementationEdmund C. Lattime, Stanton L. Gerson Academic Press, 1999 - 406 páginas Gene therapy of cancer represents a rapidly expanding field translating basic research concepts into new cutting edge technological advances. This text provides in-depth coverage of all modalities currently being used by developmental therapists to design new targeted treatments for cancer. The basic biology of cancer and cancer immunology are discussed, as are cancer targets including oncogenes, the cell cycle, induction of apoptosis, drug resistance pathways, and tumor specific antigens. Therpeautic approaches include gene replacement therapies, ribosome and antisense oligonucleotide therapies, retrovirus-mediated gene transfer, adenovirus gene transfer, nonviral approaches, tumor vaccines, engineered immunocompetent cells, and cytokine gene therapy. This comprehensive review will serve as a reference text for the field of cancer gene therapy. |
Contenido
References | 3 |
Gene Therapy of Cancer | 33 |
Retroviral Vector Design | 51 |
Derechos de autor | |
Otras 19 secciones no mostradas
Otras ediciones - Ver todas
Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to ... Stanton L. Gerson,Edmund C. Lattime Vista previa limitada - 2002 |
Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to ... Stanton L. Gerson Sin vista previa disponible - 2002 |
Términos y frases comunes
Acad activity adeno-associated virus adenovirus alleles amphotropic antibody antisense antitumor immunity apoptosis binding bystander effect cancer cells cancer gene therapy Cancer Res carcinoma CD4+ CD8+ cDNA cell cycle cell lines cellular chromosome clones complex cytokine cytotoxic deletion drug efficient encoding enhanced epitopes FHIT gene delivery gene expression Gene Ther gene therapy gene transfer genetic genome growth hammerhead hematopoietic cells HSV-TK immune response immunogenicity Immunol immunotherapy inactivation induced infection inhibition kinase leukemia lymphocytes malignant MDR1 mediated melanoma MHC class mice molecules mRNA murine mutations Natl normal oncogene overexpression patients peptide plasmid plasmid DNA potential Proc progenitors promoter protein receptor recombinant region replication resistance retroviral vectors ribozymes sequences specific stem cells strategies studies suicide gene T-cell target cell therapeutic tion tissue toxicity trans transcription transduced transfected transgene tumor antigens tumor cells tumor suppressor gene vaccines vaccinia viral Virol viruses vitro