Transformative Concepts for Drug Design: Target Wrapping
Springer Berlin Heidelberg, 2014 M12 5 - 230 páginas
In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. This book squarely addresses this crucial problem since it introduces fundamental discoveries in basic biomolecular research that hold potential to broaden the technological base of the pharmaceutical industry. The book takes a fresh and fundamental look at the problem of how to design an effective drug with controlled specificity. Since the novel transformative concepts are unfamiliar to most practitioners, the first part of this book explains matters very carefully starting from a fairly elementary physico-chemical level. The second part of the book is devoted to practical applications, aiming at nothing less than a paradigm shift in drug design. This book is addressed to scientists working at the cutting edge of research in the pharmaceutical industry, but the material is at the same time accessible to senior undergraduates or graduate students interested in drug discovery and molecular design.
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This great work by Ariel Fernandez is a pleasure to read and highly rewarding. It covers a lot of ground, from statistical physics to rational drug design, building the scientific foundations of the latter. The book advocates that epistructural biology and not structural biology is truly the supporting field to rationally develop drug designs with therapeutic value. I enthusiastically recommend this book.
Ariel Fernandez’ Transformative Concepts for Drug Design is very enjoyable and rewarding. Its conceptual richness , beautiful style, and the breadth of interwoven disciplines, from Statistical Thermodynamics to Molecular Medicine, make it a very valuable and unique asset. The book offers solutions to core problems in Biophysics and will surely leave its mark in the literature as a pioneer foray into the scientific foundations of Molecular Medicine. This is a towering achievement for its breadth and depth of knowledge.