Vitamin D: Metabolism and FunctionSpringer Science & Business Media, 2012 M12 6 - 80 páginas Because diseases of the bone are often less acute and less lifethreatening than dis eases of the circulatory system, gastrointestinal tract, kidney, liver, and the nervous system, they have received a disproportionately smaller amount of attention in the medical world. With the average increasing life span of man as a result of improve ments in modern medicine, espe~ially in the pediatric field, the seriousness of many metabolic bone diseases has indeed become more obvious. In addition, other improvements in medicine, such as hemodialysis for the preservation of renal failure patients, have permitted the development of other consequences of diseased kidneys, one of which is the appearance of renal osteodystrophy. Finally, the appearance of several genetic disorders in the area of metabolic bone disease has been underscored by the solution of other pediatric diseas~s of much more serious consequences. These emerging problems all suggest that much remains to be learned concerning the sys temic control of bone, both as a structural organ and as a reservoir for the important elements of calcium and phosphorus so essential for the support of life in complex multicellular organisms of which man is the most important. As will be demonstrated in the historical portion of this manuscript, the existence of the three most important humoral factors regulating bone metabolism and func tion are now known. |
Contenido
Acknowledgments | |
Metabolism of 25Hydroxyvitamin D | |
Metabolism of Vitamin D | |
Regulation of 125Dihydroxyvitamin D | |
Regulation of Vitamin D MetabolismbytheSex Hormones VI Mechanisms ofRegulationof | |
Endocrine System F Functions ofVitamin D | |
Factors which Regulate Intestinal Calcium Transport | |
IntestinalPhosphate Transport | |
Kidney | |
lαHydroxyvitamin D | |
Other AnalogsofVitaminD | |
Bone Calcium Mobilization | |
Calcium and ParathyroidHormone | |
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Términos y frases comunes
1,25 dihydroxycholecalciferol 1,25dihydroxyvitamin 1hydroxylase 25hydroxycholecalciferol 25hydroxylation 25hydroxyvitamin amountsof analogs animals appears ASSERMAN Baelen binding protein Biochem Biochemistry Biol biological activity Biophys brush border bythe calcium and phosphorus calciumbinding protein CHACHTER Chem chemical synthesis chromatin Clin colleagues compound cytosol cytosol receptor DeLuca DeLuca,H.F. demonstrated dietary calcium dihydrotachysterol dihydroxycholecalciferol dihydroxyvitamin Eisman endocrine systems Endocrinology etal Favus glucocorticoids Harrison hasbeen Haussler Hector F Heidelberg 1979 Holick hypocalcemia hypoparathyroidism hypophosphatemia ICOLAYSEN increased intestinal calcium absorption intestinal calcium transport inthe kidney levels Metabolism and Function metabolite of vitamin mineralization mitochondria Monographs on Endocrinology Norman Nutr ODICEK ofcalcium ofthe ofvitamin OHD onthe osteoblasts osteomalacia parathyroid glands parathyroid hormone parathyroid hormone secretion phosphate transport phosphorus Physiol plasma Proc production rachitic radioactive regulation renal osteodystrophy resorption rickets role Schnoes serum calcium concentration specific SpringerVerlag Berlin stimulates suppression synthesis Tanaka thatthe thatvitamin tissue tothe vitamin D metabolites vitamin Ddeficient vitro vivo