Vaccine Adjuvants and Delivery SystemsManmohan Singh John Wiley & Sons, 2007 M08 3 - 470 páginas The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals. |
Contenido
| 1 | |
2 Antigen Processing and Presentation | 33 |
3 Mechanisms of Adjuvant Action | 53 |
4 AluminumContaining Adjuvants Properties Formulation and Use | 81 |
5 MF59 A Safe and Potent OilinWater Emulsion Adjuvant | 115 |
6 TLR4 Agonists as Vaccine Adjuvants | 131 |
7 Immunostimulatory CpG Oligodeoxynucleotides as Vaccine Adjuvants | 157 |
8 Small Molecule Immunopotentiators as Vaccine Adjuvants | 175 |
11 Liposomal Cytokines and Liposomes Targeted to CoStimulatory Molecules as Adjuvants for HIV Subunit Vaccines | 249 |
12 Archaeosome Vaccine Adjuvants for CrossPriming CD8+ TCell Immunity | 263 |
13 Mucosal Adjuvants and Delivery Systems | 295 |
14 Cytokines as Vaccine Adjuvants | 327 |
15 Polyphosphazenes as Vaccine Adjuvants | 355 |
16 Vaccine Delivery by Transdermal Electroporation | 379 |
17 Nonclinical Safety Assessment of Vaccines and the Evaluation of Novel Adjuvants and Delivery Systems | 403 |
18 Safety Evaluation of Vaccine Adjuvants | 421 |
9 New ISCOMs Meet Unsettled Vaccine Demands | 191 |
10 SurfaceCharged Polylactidecoglycolide Microparticles as Novel Antigen Delivery Systems | 223 |
Otras ediciones - Ver todas
Términos y frases comunes
acid adju adjuvant activity adjuvant effect administration adsorbed adsorption agonists alum aluminum hydroxide aluminum hydroxide adjuvant aluminum phosphate adjuvant aluminum-containing adjuvants animal antibody antibody responses antigen antigen-specific APCs archaeosomes bacterial cancer CD4+ CD8+ T cells cellular CpG ODNs cytokines cytotoxic delivery systems dendritic cells DNA vaccines dose effector emulsion enhanced entrapped evaluated formulations gene GM-CSF hepatitis human imiquimod immu immune responses immune system immunogenicity Immunol immunological immunological adjuvants induced Infect Immun influenza vaccine influenza virus innate immune intranasal ISCOM ISCOM-Matrix lipid liposomes lymphocytes macaques macrophages MHC class mice microspheres molecules mucosal immune murine novel O’Hagan oral ovalbumin particles pathogens pathway PCPP peptide plasmid PLG microparticles polymer polyphosphazene potential protection protein recombinant safety saponin serum skin stimulation studies subunit surface synthetic T-cell T-cell responses targeting tion titers TLR4 Toll-like receptor toxicity toxin toxoid tumor uptake vaccine adjuvants vectors viral Virol viruses vitro vivo