Avian InfluenzaHans-Dieter Klenk, Mikhail N. Matrosovich, Jürgen Stech Karger Medical and Scientific Publishers, 2008 M01 1 - 292 páginas Because of its high impact on both animal and human health, avian influenza has become a matter of increasing public concern and growing scientific interest within the last decade. This volume gives an overview of the most important results of these research efforts and provides information about the ecology and epidemiology of avian influenza with particular emphasis on recent H5N1 outbreaks in China, Siberia and Europe. Several articles deal with new vaccination strategies, the use of antivirals and other control measures to combat outbreaks of avian influenza. Further chapters illustrate that molecular biology, culminating in the generation of influenza viruses by recombinant DNA technology, was instrumental in unravelling the roles of the viral hemagglutinin and polymerase as well as cellular signalling pathways and innate immunity in pathogenesis and interspecies transmission. Finally, the threat of a pandemic originating from avian influenza viruses is illustrated by the example of the Spanish influenza of 1918.This comprehensive publication on avian influenza viruses and their relevance for human influenza will be of great value to all influenza virologists, molecular biologists, public health scientists, veterinary virologists, ecologists, and scientists engaged in drug design and vaccine development. |
Contenido
Epidemiology of Avian Influenza | 1 |
H5N1 in Asia | 11 |
Epidemiology and Control of H5N1 Avian Influenza in China | 27 |
Avian Influenza in Northern Eurasia | 41 |
Avian Influenza in Italy 19972006 | 59 |
Avian Influenza Outbreaks in Germany Development of New Avian Vaccines | 71 |
The Role of Pigs in Interspecies Transmission | 88 |
History of Research on Avian Influenza | 101 |
Transcription and Replication | 168 |
A Determinant of Host Range and Pathogenicity | 187 |
Recent Insights from New Mouse Models | 195 |
Influenza Viruses and Intracellular Signal Transduction Cascades | 210 |
Cytokines in the Pathogenesis of Highly Virulent Influenza Viruses in Humans | 225 |
Antivirals and Resistance | 252 |
Lessons from the Past Raise Questions for the Future | 272 |
287 | |
Reverse Genetics of Influenza Viruses Applications in Research and Vaccine Design | 118 |
Receptor Specificity of Influenza Viruses and Its Alteration during Interspecies Transmission | 134 |
Cleavage Activation of the Influenza Virus Hemagglutinin and Its Role in Pathogenesis | 156 |
Términos y frases comunes
Acad Sci USA activation amantadine amino acid antigenic antiviral avian influenza viruses avian viruses bar-headed geese binding cellular chemokines chickens China cleavage cytokines disease ducks emergence Garcia-Sastre Gen Virol genome H5N1 avian influenza H5N1 influenza viruses H5N1 viruses hemagglutinin highly pathogenic avian Hong Kong host HP H5N1 HPAI viruses HPAIV human influenza immune induced influenza virus influenza virus infection inhibitors interaction interferon Kawaoka kinase Klenk HD lethal LPAI lungs Lvov Lvov DK mice Molecular mRNA mutations Natl Acad Sci neuraminidase NS1 protein oseltamivir outbreaks Palese pandemic pathogenic avian influenza pathway Peiris pigs polymerase complex Proc Natl Acad reassortant receptor specificity recombinant resistance reverse genetics rimantadine RNA polymerase role Scholtissek sequences sialic acid species structure studies subtype subunit swine Taubenberger JK tion transcription transmission vaccine viral viral RNA Virology virulence virus replication virus RNA viruses isolated vRNA waterfowl Webster RG wild birds zanamivir