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This great work by Ariel Fernandez is a pleasure to read and highly rewarding. It covers a lot of ground, from statistical physics to rational drug design, building the scientific foundations of the latter. The book advocates that epistructural biology and not structural biology is truly the supporting field to rationally develop drug designs with therapeutic value. I enthusiastically recommend this book. 

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Ariel Fernandez’ Transformative Concepts for Drug Design is very enjoyable and rewarding. Its conceptual richness , beautiful style, and the breadth of interwoven disciplines, from Statistical Thermodynamics to Molecular Medicine, make it a very valuable and unique asset. The book offers solutions to core problems in Biophysics and will surely leave its mark in the literature as a pioneer foray into the scientific foundations of Molecular Medicine. This is a towering achievement for its breadth and depth of knowledge. 

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