An Introduction to ImmunologyCRC Press, 2002 - 511 páginas In An Introduction to Immunology, the author includes the most recent information while emphasizing the basic fundamentals of each topic so that you obtain a broad outline of the subject. The text elucidates fundamental concepts, such as the origin of the immune system, innate and acquired immunity, and cells and organs of the immune system. It discusses recent concepts and ideas regarding innate and acquired immunity, T-cell and B-cell activation and differentiation mechanisms, factors involved in rheumatoid arthritis, T-cell clonal anergy, NK cell receptors, strategies in production of new vaccines against pathogens, new information on the minor histocompatibility complex, and much more. Moreover, the author brings you up to date with the latest developments by reviewing recently proposed concepts on transplantation immunology, blocking of costimulatory signals, CTLA-4 mediated T-cell inhibition, immune tolerance, NK cell tolerance, HLA delivered peptides for immunosuppression, and tumor antigens coded by oncogens. Covering subject matter based on the immunology course taught by the author for the past twenty years, Introduction to Immunology is an excellent text for graduate and postgraduate students, as well as a good reference book for teachers of biological sciences. |
Contenido
CHAPTER | 1 |
References | 13 |
Second Line of Defense | 19 |
Mechanism of Innate Immune Recognition | 28 |
Live attenuated vaccines | 36 |
Factors Affecting Immune System | 43 |
CELLS AND ORGANS OF IMMUNE SYSTEM | 46 |
GranulocytesNeutrophils | 53 |
EFFECTOR RESPONSES | 241 |
Features of memory cells | 259 |
Role of B cells in T cell memory | 261 |
Functions of Cytokines | 267 |
Cytokines that Regulate Immune Mediated Inflammation | 283 |
Cytokine related diseases | 286 |
Alternative Complement Pathway | 294 |
Complement Deficiencies | 303 |
Secondary Lymphoid Organ | 59 |
Function of IELCytolytic activity Helper activity | 65 |
Cutaneous Associated Lymphoid Tissue | 73 |
Role Played by Biological System in Immunogenicity | 81 |
CHAPTER 6 | 87 |
Peptide interaction with MHC molecules | 93 |
ANTIBODIES IMMUNOGLOBULINS 102118 | 102 |
Immunoglobulin Classes | 109 |
References | 117 |
Agglutination reaction | 128 |
Radio allergosorbent test | 134 |
References | 140 |
Mechanism of Variable Region DNA Rearrangements | 148 |
Expression of Ig Genes | 157 |
BCELL MATURATION ACTIVATION | 163 |
Overview of major pathways of BCR signaling | 169 |
BCell coreceptor complex | 176 |
TCELL MATURATION ACTIVATION | 184 |
T cell Activation | 191 |
Costimulation in Tcell response | 200 |
T cell Differentiation | 206 |
TCELL AND BCELL RECEPTORS 213231 | 213 |
Tcell Accessory Membrane Molecules | 219 |
CHAPTER 13 | 232 |
References | 239 |
Vaccines from purified macromolecules | 310 |
Shigella O antigen specific conjugates | 313 |
Vaccines from synthetic peptides | 319 |
Viral Strategies of Immune evasion | 327 |
Immune response against Protozoan Parasites | 334 |
Immune response against Helminth parasites | 339 |
Components Involved in Type I Reaction | 345 |
Passive transfer anaphylaxis | 353 |
Hypersensitivity or Antibody | 359 |
CHAPTER 20 | 368 |
Mechanism of graft rejection | 374 |
Specific immunosuppressive therapy during transplantation | 382 |
Polymorphic MHC derived peptides | 387 |
CHAPTER 21 | 393 |
nature of immature Tcells | 399 |
Mechanism of homeostasis Returning the immune | 405 |
Immune response to tumor antigens | 420 |
Cytokine therapy | 429 |
Pathogenesis Rheumatoid arthritis | 437 |
Experimental therapeutic approach | 442 |
Cell mediated deficiencies | 452 |
GLOSSARY 457482 | 457 |
INDEX 483507 | 483 |
Términos y frases comunes
alleles amino acid anergy antibody antigen presenting autoimmune disease bacterial binding blood bone marrow CD4+ T cells CD8+ cell activation cell receptor cell-mediated cellular class II MHC complement complex component Curr cytokines cytoplasmic cytotoxic dendritic cells differentiation domain effector encoding enhanced enzyme eosinophils epitopes expression factor function gene segments graft heavy chain host human hypersensitivity IFN-y immune response immune system immunogenic immunoglobulin Immunol induce infection inflammatory inhibition interaction intracellular involved kinase ligand light chain lymph lymphocytes lymphoid macrophages mast cells mature mechanism mediated membrane memory B cells memory cells MHC molecules mice molecular neutrophils NK cells Opin pathogens pathway peptides phagocytic phagocytosis phosphorylation plasma cells production proliferation protein reaction rearrangement recombination regulation role secreted sequence serum specific stimulation surface T-cell target cell TH cells thymocytes thymus tissue transplantation tumor tumor cells tyrosine vaccines viral virus viruses