An Introduction to Immunology

Portada
CRC Press, 2002 - 511 páginas
In An Introduction to Immunology, the author includes the most recent information while emphasizing the basic fundamentals of each topic so that you obtain a broad outline of the subject.

The text elucidates fundamental concepts, such as the origin of the immune system, innate and acquired immunity, and cells and organs of the immune system. It discusses recent concepts and ideas regarding innate and acquired immunity, T-cell and B-cell activation and differentiation mechanisms, factors involved in rheumatoid arthritis, T-cell clonal anergy, NK cell receptors, strategies in production of new vaccines against pathogens, new information on the minor histocompatibility complex, and much more. Moreover, the author brings you up to date with the latest developments by reviewing recently proposed concepts on transplantation immunology, blocking of costimulatory signals, CTLA-4 mediated T-cell inhibition, immune tolerance, NK cell tolerance, HLA delivered peptides for immunosuppression, and tumor antigens coded by oncogens.

Covering subject matter based on the immunology course taught by the author for the past twenty years, Introduction to Immunology is an excellent text for graduate and postgraduate students, as well as a good reference book for teachers of biological sciences.
 

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Contenido

CHAPTER
1
References
13
Second Line of Defense
19
Mechanism of Innate Immune Recognition
28
Live attenuated vaccines
36
Factors Affecting Immune System
43
CELLS AND ORGANS OF IMMUNE SYSTEM
46
GranulocytesNeutrophils
53
EFFECTOR RESPONSES
241
Features of memory cells
259
Role of B cells in T cell memory
261
Functions of Cytokines
267
Cytokines that Regulate Immune Mediated Inflammation
283
Cytokine related diseases
286
Alternative Complement Pathway
294
Complement Deficiencies
303

Secondary Lymphoid Organ
59
Function of IELCytolytic activity Helper activity
65
Cutaneous Associated Lymphoid Tissue
73
Role Played by Biological System in Immunogenicity
81
CHAPTER 6
87
Peptide interaction with MHC molecules
93
ANTIBODIES IMMUNOGLOBULINS 102118
102
Immunoglobulin Classes
109
References
117
Agglutination reaction
128
Radio allergosorbent test
134
References
140
Mechanism of Variable Region DNA Rearrangements
148
Expression of Ig Genes
157
BCELL MATURATION ACTIVATION
163
Overview of major pathways of BCR signaling
169
BCell coreceptor complex
176
TCELL MATURATION ACTIVATION
184
T cell Activation
191
Costimulation in Tcell response
200
T cell Differentiation
206
TCELL AND BCELL RECEPTORS 213231
213
Tcell Accessory Membrane Molecules
219
CHAPTER 13
232
References
239
Vaccines from purified macromolecules
310
Shigella O antigen specific conjugates
313
Vaccines from synthetic peptides
319
Viral Strategies of Immune evasion
327
Immune response against Protozoan Parasites
334
Immune response against Helminth parasites
339
Components Involved in Type I Reaction
345
Passive transfer anaphylaxis
353
Hypersensitivity or Antibody
359
CHAPTER 20
368
Mechanism of graft rejection
374
Specific immunosuppressive therapy during transplantation
382
Polymorphic MHC derived peptides
387
CHAPTER 21
393
nature of immature Tcells
399
Mechanism of homeostasis Returning the immune
405
Immune response to tumor antigens
420
Cytokine therapy
429
Pathogenesis Rheumatoid arthritis
437
Experimental therapeutic approach
442
Cell mediated deficiencies
452
GLOSSARY 457482
457
INDEX 483507
483
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