Research Progress in Alzheimer's Disease and Dementia, Volume 2

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Nova Publishers, 2006 - 378 pages
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Alzheimer's disease (AD), the most common type of neurodegenerative disorder in the aging population, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive dementia. The rapid progress in the research fields of AD and dementia continues since the publication of the first book volume with the same title. This second book volume contains 14 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics range from defining deregulation of amyloid precursor protein (APP) processing and neurotransmitter and signal molecules involved in regulation of APP processing, transgenic AD mouse models and their relevance to AD research, amyloid -peptide (A) immunisation, cerebral inflammation, myelin breakdown, roles of deregulation of cell cycle in AD pathology, relationship between cholesterol and AD, A binding to cholesterol and cholesterol oxidation, A-binding alcohol dehydrogenase and roles in AD pathogenesis, sex steroids, oestrogen therapy for AD prevention, behavioural and psychological symptoms of AD, memantine for AD therapy, enoxaparin as a therapeutic agent for AD, to molecular links between AD and traumatic brain injury. The prospects for developing effective therapeutic agents that target memory-relevant AD pathogenesis, as shown in these chapters written by world-wide leaders in the fields, are more encouraging. The book will be highly valuable to students and scientists world-wide who are interested in the scientific research progress in AD and dementia.
 

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Contents

Regulation of Synthesis and Metabolism of the Amyloid Precursor Protein by Extracellular Signals
1
Modelling Alzheimers Disease What Can We Learn from Mice?
27
Cerebral Inflammation and Alzheimers Disease
57
Myelin Breakdown Trajectories and Risk Factors for AgeRelated Cognitive Decline and Alzheimers Disease
97
Alzheimers Disease A Deregulated Cell Cycle Disease
109
Cholesterol Statins and Alzheimers Disease Past Present and Future
123
Cholesterol Oxidation and PAmyloid Perspectives on Alzheimers Disease and Therapy
137
ABAD Mitochondrial Target for APMediated Cellular Perturbation in Alzheimers Disease
175
The Role of Sex Steroids in Alzheimers Disease and AgeRelated Cognitive Decline
191
Estrogen Therapy for Preventing Alzheimers Disease Therapeutic Strategies to Address Hormone Therapy Challenge for the Brain
227
Behavioral and Psychological Symptoms of Alzheimers Disease
251
Memantine for Alzheimers Disease
273
Enoxaparin as a Therapeutic Agent for Alzheimers Disease
307
Head Injury and Dementia
327
Index
357
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About the author (2006)

Miao-Kun Sun, Ph.D. obtained his Ph.D. at the Department of Pharmacology, University of Virginia, in 1986, and continued postdoctoral research at the same department for two more years. After a brief research period (one year) at the Department of Physiology, Royal Free Hospital School of Medicine, University College of London, he accepted a faculty position at Department of Neurology and Neuroscience, Cornell University Medical College in New York in 1990. His current position is Professor at Blänchette Rockefeller Neurosciences Institute (holding the same position since 2000).

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