Front cover image for Transformative Concepts for Drug Design: Target Wrapping

Transformative Concepts for Drug Design: Target Wrapping

Ariel Fernandez (Author)
In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. This book squarely addresses this crucial problem since it introduces fundamental discoveries in basic biomolecular research that hold potential to broaden the technological base of the pharmaceutical industry. The book takes a fresh and fundamental look at the problem of how to design an effective drug with controlled specificity. Since the novel transformative concepts are unfamiliar to most practitioners, the first part of this book explains matters very carefully starting from a fairly elementary physico-chemical level. The second part of the book is devoted to practical applications, aiming at nothing less than a paradigm shift in drug design. This book is addressed to scientists working at the cutting edge of research in the pharmaceutical industry, but the material is at the same time accessible to senior undergraduates or graduate students interested in drug discovery and molecular design
eBook, English, 2010
Springer Berlin Heidelberg, Berlin, Heidelberg, 2010
1 online resource (234 p.)
9783642424588, 9783642117923, 3642424589, 3642117929
1113040847
Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy
Wrapping Defects and the Architecture of Soluble Proteins
Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins
Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design
Under-Wrapped Proteins in the Order-Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation
Evolution of Protein Wrapping and Implications for the Drug Designer
Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence
Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects
Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways
Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact
Inducing Folding By Crating the Target
Wrapper Drugs as Therapeutic Editors of Side Effects
Wrapper Drugs for Personalized Medicine
Last Frontier and Back to the Drawing Board: Protein-Water Interfacial Tension in Drug Design
Description based upon print version of record
English